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KMID : 0352819890050020027
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Kosin Medical Journal
1989 Volume.5 No. 2 p.27 ~ p.36
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BIOCHEMICAL STUDIES OF BLOOD COMPONENTS, LIPOGENIC AND LIPOLYTIC ENZYMES IN TUMOR BEARING ANIMALS
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Lee, Song Jae
Jeong, In Cheol/Cho, Moo Youn
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Abstract
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Attempts were made to elucidate biochemical mechanisms causing depletion and hypulipidemia of body fat in Tumor-bearing animals. The changes of blood components, lipogenic and lipolytic enzyme activities were studied in mice with Sarcoma 180 tumor cells.
The following results were obtained.
1. The total carcass lipid of tumor-bearing mice was significantly decreased during the growth of tumor cells.
2. The plasma triglyceride and free fatty acid levels of tumor-bearing mice were remarkably increased, but plasma insulin and glucose levels were decreased in response to tumor cell growth.
3. At the same time, the activities of enzymes responsible for lipogenesis and lipolysis such as glucose-6-phosphate dehydrogenase and hepatic triglyceride lipase were significantly reduced in the liver and adipose tissue of tumor-bearing mice.
From the above results, the observed body fat depletion and hyperlipidemia in response to tumor cell growth might in part due to the cumulative effect of insulin and decreased enzymatic activity responsible for lipogenesis in the liver and adipose tissue of tumor-bearing mice.
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KEYWORD
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